What are the second messengers in the GPCR-phospholipase c signal transduction system?
Answer: DAG (Diacylglycerol) and IP3 (Inositol triphosphate).
Explanation: In general, binding of ligand to a GPCR (receptor) activates the effector, phospholipase C (PLC) to produce two-second messengers such as DAG and IP3 from phosphatidylinositol 4,5-bisphosphate (PIP2). The released DAG and IP3 stereospecifically activate the target enzyme, protein kinase C (PKC), and release the calcium from intracellular organelles.
Other important questions:
Q. The alpha-helix and beta-sheet are found at which level of protein organization?
Q. Which cytoskeletal proteins provide the structural support for microvilli?
Q. Which of these does not contain a structural protein?
Q. What level of protein structure is associated with the sequence of amino acids?
Q. Which of the following pertains to typhoid fever?
Q. Which of the following tests is an agglutination test for the bacterium causing typhoid fever?
Q. This is a compound made from a group of covalently bonded atoms?
Q. If two covalently bonded atoms are identical the bond is?
Q. Which of the following are characteristics of G protein-coupled receptors (GPCR)?