What are the second messengers in the GPCR-phospholipase c signal transduction system?
Answer: DAG (Diacylglycerol) and IP3 (Inositol triphosphate).
Explanation: In general, binding of ligand to a GPCR (receptor) activates the effector, phospholipase C (PLC) to produce two-second messengers such as DAG and IP3 from phosphatidylinositol 4,5-bisphosphate (PIP2). The released DAG and IP3 stereospecifically activate the target enzyme, protein kinase C (PKC), and release the calcium from intracellular organelles.
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